For comparison of the NCA results, we selected the following conditions: extravascular, linear-up linear-down, and best fit. The results are significant as they offer insights on the potential for food-drug interactions between carnosol from rosemary and active pharmaceutical ingredients. Validation of NCA results between R packages and WinNonlin® To demonstrate the accordance of outputs by ncar package and WinNonlin®, we performed NCA using Theoph dataset obtained from the R software. The maximum plasma concentration exceeded 1 μM after a single administration.
Note that datasets D and B give the same results this is expected since the within-subject treatment ratios (or the logarithmic within-subject treatment. Mice were administered carnosol (100 mg/kg body weight) by oral gavage and plasma levels were analyzed by LC-MS/MS to establish a detailed pharmacokinetic profile. Table I lists the datasets along with the evaluations obtained with the different statistical packages EquivTest/PK, Kinetica (5.0.10), SAS (9.2), Phoenix/WinNonlin (6.3.0.395), and R (3.0.2).
The present study utilizes cell-free, cell-based, and animal-based experiments to define the pharmacokinetic profile of the food based phytochemical carnosol. For example, the sandwichpackage vignette is opened using 6.
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Rosemary ( Salvia Rosmarinus) is a rich source of dietary diterpenes with carnosol as one of the major polyphenols used to standardize rosemary extracts approved as a food preservative, however, at present there is not any information on the murine pharmacokinetic profile of carnosol or its potential for drug interactions. and graphics tools with the same user interface that is used in Phoenix WinNonlin. These resources are very useful and can u please help me in finding some basics about PK modelig and also how to acheive it using winnonlin.
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